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Cyclosporin, the drug that issued in the modern era of immunosuppression and thus solid organ transplant was discovered in a soil sample from Hadangervidda in Norway (roughly between Oslo and Bergen). It is a product secreted by a fungus that helps suppress the highly conserved phosphatase, calcineurin.
Other immunosuppressants, like tacrolimus and sirolimus were discovered in soil samples from Japan and Easter Island respectively.
Isn’t pharmacognosy fun?
Random thoughts and experiences
